Dr F. Ivy Carroll - 2012
"DESIGN AND DEVELOPMENT OF OPIOID RECEPTOR ANTAGONISTS FOR SUBSTANCE ABUSE RESEARCH" Dr F. Ivy Carroll
Distinguished Fellow in Medicinal Chemistry
Former Director of the Center for Organic and Medicinal Chemistry (1975-2007) and former Research Vice President of the Chemistry and Life Sciences Group (1996-2001).
Research Triangle Institute (RTI International) - Durham, North Carolina, USA
Opiates, cocaine, methamphetamine, nicotine, and alcohol abuse have been and still remain major public health problems. This address will highlight our studies directed toward the design and development of opioid receptor antagonists as pharmacological and clinical research tools for use in obtaining a better understanding of substance abuse disorders. The main focus will be on the development of the selective kappa opioid receptor antagonist JDTic. Studies leading to selective mu and delta opioid receptor antagonists and delta inverse agonists will also be presented. All studies presented have been supported by the National Institute on Drug Abuse (NIDA).