Dr Gavril Pasternak - 2015
"40 years on drugs: It’s all in the telling of the tail"
Dr Gavril Pasternak
Memorial Sloan-Kettering Cancer Center
Opioids are unique in that our extensive clinical experience with them predated the identification of their receptor targets. Over the past 40 years, our understanding of opioid action at the molecular level has evolved to provide insights into the extraordinary complexity of opioids and their targets implied by decades of clinical observation